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Centrifugal extraction machine applied in the synthesis of ibuprofen ketal washed process

by:Deyuan      2020-08-21
Ibuprofen for a new generation of non-steroidal anti-inflammatory analgesic drug, has a stronger than aspirin antipyretic, anti-inflammatory and analgesic effects, side effects are much smaller than aspirin. So since the late 1970 s, with its high curative effect, side effect small wei characteristics and obtained the rapid development, has now become the production and use one of the largest anti-inflammatory and antipyretic analgesics.

at present domestic manufacturer is generally used to synthesis method of ibuprofen rearrangement. Using butyl benzene as raw materials, with 2 - Chlorine propionyl chloride friedel-crafts acylation and extraneous butyl benzene as raw material, by friedel-crafts acylation with chlorine propionyl chloride butyl glycol ketal catalyzed chemical, catalytic rearrangement, hydrolysis system such as ibuprofen. The advantages of simple operation stability, shorter. Should be in the process of synthesis of ketal washed to neutral and can take the next step of synthesis. Usually in reaction kettle in the industrial production of ketal washed, this method takes longer, washing effect is not stable, and can't realize the continuous production.



some pharmaceutical companies in shandong ibuprofen production workshop of synthetic fluid capacity of 10 m after/h, the CWL550 - M type centrifugal extraction machine for ketal washed. The processing speed faster, better separation effect, after washing ketal may go into the next synthesis section. Actual processing equipment after 15 m/h, greatly shorten the production time, improve the production, obtained obvious economic benefits.
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