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Chinese medicine extraction and separation and determination of the organic acid

by:Deyuan      2020-09-05
The extraction and separation of the components of organic acids in the traditional Chinese medicine (TCM) are reviewed and the determination methods are reviewed. Along with natural products chemistry and pharmacology research and analysis method is by leaps and bounds in the development of traditional Chinese medicine (TCM) the study of the composition of organic acids has attracted many scholars at home and abroad of great interest. Natural organic acid resources are rich in our country, in traditional Chinese medicine (TCM) has found more kinds and amount of the components of organic acids, a growing number of studies have demonstrated that the composition of organic acids in the traditional Chinese medicine (TCM) have a wide range of biological activities. Traditional and modern extraction and separation and determination of methods have their own advantages and disadvantages, adopt appropriate extraction and separation and determination method, not only can improve the efficiency of extraction and detection, also can bring convenience for further extraction and separation of organic acids and determination.
1。 Traditional Chinese medicine (TCM) in the choice of organic acid extraction and separation methods are mainly based on its structural properties of different methods to determine.
1。 Base 1 mention acid sinking method
come salt or organic acids in plants is free, water or dilute alkaline ( Such as sodium bicarbonate 1%) Directly extract, extract leach precipitation after acidification, extract after adding inorganic acid acidification, total free organic acid precipitation, filtration or non-polar organic solvent extraction method of total organic acids. XXL by comparing the ultrasonic extraction method is adopted, such as alkali acid sinking method, acid sinking after organic solvent extraction, organic solvent and acid water methods such as direct extraction method to extract the goose not herbivorous total organic acid, and spectrophotometry determination of total organic acid content. Results found that alkaline acid sinking method for the goose is not herbivorous total organic acid extraction method, total organic acid content is 67. 3%.
1。 Organic solvent extraction
2 solvent extraction generally refers to the method of the effective parts extracted from Chinese herbal medicine, according to the Chinese herbal medicine in the solubility of components in the solvent, the selection of active ingredient solubility, don't need a dissolution composition small solubility of solvent, and dissolved the effective ingredients from medicinal herbs in the organization. As a result of the free organic acids ( Except for small molecular weight) Soluble in organic solvents and poorly soluble in water, organic acid salt is soluble in water and soluble in organic solvents, so can let whole organic acid acidification commonly free, then choose a suitable organic solvent extraction. Zhang, etc by using the orthogonal experiment optimization xuan papaya total organic acid, with different ethanol concentration on xuan papaya extract, extraction process for ethanol concentration 80%, material liquid than in 25, extraction temperature is 90 ℃, extraction time is 3 h, xuan papaya yield of total organic acids to 10. 46%, which indicates that this process is stable, feasible and suitable for industrial im � � �.


2 solvent extraction
generally refers to the method of the effective parts extracted from Chinese herbal medicine, according to a variety of ingredients in Chinese herbal medicine solubility in the solvent selection for active ingredient solubility, dissolution unwanted components solubility of solvent, and dissolved the effective ingredients from medicinal herbs in the organization. As a result of the free organic acids ( Except for small molecular weight) Soluble in organic solvents and poorly soluble in water, organic acid salt is soluble in water and soluble in organic solvents, so can let whole organic acid acidification commonly free, then choose a suitable organic solvent extraction. Zhang, etc by using the orthogonal experiment optimization xuan papaya total organic acid, with different ethanol concentration on xuan papaya extract, extraction process for ethanol concentration 80%, material liquid than in 25, extraction temperature is 90 ℃, extraction time is 3 h, xuan papaya yield of total organic acids to 10. 46%, which indicates that this process is stable, feasible and suitable for industrial production.
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lu an investigation of low temperature enzyme solution such as auxiliary ethanol extraction instead of traditional ethanol reflux extraction of greengage organic acid yield, the results showed that pectinase of greengage digestion ability significantly, the main factors influencing the effect of greengage organic acid extraction for enzyme digestion temperature, digestion time, adding amount. Greengage organic acids in the appropriate enzyme assisted extraction technological conditions of extraction for the adding quantity of 31. 6 u/mL, enzymolysis temperature 45. 67 ℃, enzymolysis time 3. 41 h, extract the corresponding total organic acid extraction yield of 35. 49%, compared with traditional ethanol reflux extraction yield ( 29. 10%) Have improved significantly.
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