Chinese medicine extraction equipment extracting lincomycin process
Clindamycin refining process is mainly divided into the fermented liquor pretreatment and filtering, extracting and refining steps, tianyi extraction factory in order to improve the yield and quality, improve the production process to develop Chinese medicine extraction equipment extracting lincomycin new process technology.
Chinese medicine extraction equipment extracting lincomycin process when the fermented liquid 1.
6 m3 concentration to 795 ug/mL, adjust pH to 8, with methylene chloride 350 l add have 2% dinonyl naphthalene sulfonic acid, extracting machine contact in traditional Chinese medicine extraction equipment, the yield can reach 98%.
Organic phase concentration to 30 l, and then add 2 octyl amine.
2 l and 5 l of water.
Stir mixture with HCl adjust pH to 3, 5 min and then separated.
Organic phase to water washing four times.
Combined water extraction liquid, clindamycin in aqueous phase can be further refined, in pH10 into free alkali, mentioned in methylene chloride, finally crystallization in the form of hydrochloric acid, the total yield of 83%.