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Prasugrel hydrochloride reagent preparation of synthesis of new extraction process

by:Deyuan      2020-08-26
Prasugrel hydrochloride, indications for suitable for acute and chronic bronchitis, asthma, pneumonia, tuberculosis, antitussive and expectorant diseases such as emphysema.
styrene acrylic ketone of pp for both central and peripheral antitussive effect of non addictive cough medicine, the main effect on cough central. Animal experiments showed that selective inhibition of brainstem reticular, including cough center of medulla oblongata, its strength and codeine similar or as a third, for neither dm 2 times, 3 times that of. This product clinical antitussive effect similar to codeine or less, but no inhibitory effect of intestinal peristalsis of codeine. Expectoranting action concurrently, the product can make sputum acid glycoprotein polysaccharide in fiber properties change, mucopolysaccharide fiber fracture, have stronger mucous dissolves. In addition, the experimental results showed that this product also has a calming effect, local anesthesia effect and antihistamines, choline, alleviates the histamine and acetylcholine and 5 - Serotonin caused by bronchial smooth muscle spasm. Centrifugal extraction machine extraction principle of synthetic hydrochloric acid prasugrel by solvent
some of which were extracted from liquid mixture operation known as liquid/liquid extraction. Centrifugal extraction machine extraction is the use of components selected in the solution of the differences in the solubility of solvent, the solute of liquid-liquid mass transfer, in order to achieve the separation of homogeneous liquid mixture operation. Raw material liquid mixed with the extracting agent fully contact, complete the solute mass transfer process;
weight according to certain proportion respectively from two two phase solution and feeding tube into the drum shell ring gap formed between the mixed zone, with the aid of the rotation of the drum, through the turbine disc and the impeller to make two phase mixing and dispersing quickly, two phase solution fully mass transfer. Complete mixing and mass transfer process. Extraction and extraction residual phase separation process;
mixture under the action of vortex disk into the rotary drum, in the plate to form the bulkhead area, mixture quickly with synchronous rotary drum, in under the action of centrifugal force, the heavier than major phase fluid in the process of upward mobility and gradually away from the drum center on the drum wall; Small proportion of liquid phase gradually away from the drum wall and on to the center, after clarification of two phase fluid end respectively through their weir plate into the collection chamber and the tube was closed to derivation, respectively, to complete two phase separation process. From the extraction phase and extraction phase extractant recycling process.
usually use the method of distillation recycling extracting agent. Removal after extraction of proportion as the extractant extract; After removal from the extraction agent over extraction of proportion of extraction liquid.
new extraction process prasugrel hydrochloride preparation significance
improve prasugrel hydrochloride synthesis process, in order to enlarge production, improve product purity. The method based on adjacent fluorine benzene acetic acid and cyclopropane synthesized from methyl formate cyclopropyl - 2 - Fluorine benzyl ketone, NBS bromine generation by alpha Cyclopropyl carbonyl - 2 - Fluorine benzyl bromide in the presence of alkali, and 2 - Oxygen generation - 2,4,5,6,7,7a- Six hydrogen thiophene and [ 3, 2 - c] Pyridine hydrochloride nucleophilic substitution reaction, then through acetylation reaction and salification prasugrel hydrochloride. The optimized synthesis process is simple, low cost, can obtain high purity hydrochloric acid prasugrel. Machine with centrifugal extraction phase equilibrium in the process to build fast, easy to implement series single stage or multistage counter-current or wrong washing and extraction, high mass transfer efficiency and grade efficiency approaching 100%, stop not to undermine the established after concentration distribution at different levels, can at any time at all levels of sampling, facilitate testing. Results show that the new process output rate of 48%, is conducive to industrial production.
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