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Traditional Chinese medicine extraction technology to extract berberine hydrochloride ( Berberine) Technology research

by:Deyuan      2020-08-26
Berberine is also called berberine hydrochloride for dysentery bacillus, escherichia coli, pneumonic diplococcus, s. aureus, streptococcus pneumoniae, salmonella typhi and amoeba has inhibitory effect. Clinical mainly used in intestinal infection and bacillary dysentery, etc. Also found that this product has antiarrhythmic action. Berberine has strong antitumor activity in vivo and in vitro and can induce differentiation of B16 cells; With cytarabine HCL has synergetic effect in vitro.
currently used to extract berberine pharmaceutical industry mainly � � needle as raw materials. Three needle from berberidaceae berberis belong to many kinds of plants, and its root bark contains about 2% of alkaloids, mainly containing berberine, such as alkali, Mr Martin barberry amine, medicine alkaloids.
Chinese medicine extraction technology to extract berberine hydrochloride ( Berberine) Principle of
use berberine sulfate in water solubility is larger, and the nature of the hydrochloride is almost insoluble in water, first to convert this medicinal materials of berberine sulfate water is put forward; To make it into hydrochloride, reduce its solubility in water, combined with salting out method was berberine hydrochloride.
Chinese medicine extraction technology to extract berberine hydrochloride ( Berberine) Process problems should be paid attention to when
1, soaking with sulfuric acid, sulfuric acid concentration to 0. 2% advisable, generated at this time of berberine sulfate in the water solubility is larger, if add too much, berberine sulfate to form acid, solubility in water is lower, 1:100) , the effect of berberine extraction.
2, in the pH ~ 8. 5 the barberry amine precipitation is completely, but not easily condensed, 80 ℃ heat preservation, make the coagulation and sedimentation.
3, berberine refined sort of pH to 2, is to make the barberry amine and tertiary amine type alkaloid in solution, in order to get a pure berberine, if operation solution cooling crystallization precipitation, should be heated into transparent solution with hydrochloric acid.
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