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Traditional Chinese medicine extraction technology to extract the lipid drug penicillin

by:Deyuan      2020-08-16
Because the molecular structure of the penicillin containing carboxyl, so can the esterification, generate penicillin esters, and oral absorption, easily when the traditional Chinese medicine extraction technology to extract the lipid drug penicillin because this product is soluble in water, when pH2 is stable, good oral absorption, its synthesis method is the ammonia cut penicillin extraction to organic phase esterification, and insoluble in organic phase ammonia cut penicillin. Want to join - phase transfer agent - - Intermediate generated quaternary ammonium salt, the soluble in water, which can dissolve in organic phase, after reaction, the reaction products, high yield, to join the extraction mechanism of the reaction, phase transfer agent then reverse extraction in aqueous solution, further treatment by ammonia making penicillin phthalic ester hydrochloride.
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