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urinary bisphenol a and plasma hormone concentrations in male workers exposed to bisphenol a diglycidyl ether and mixed organic solvents

by:Deyuan      2020-09-14
To evaluate the exposure of diphenol A- dishrink-glycerin ether (BADGE)
A study on the excretion, plasma stimulating hormone and testosterone in urine of male epoxy sprayer.
Methods: cross sections were carried out on 42 workers who worked to spray epoxy hardening agents including badges and mixed organic solvents and 42 matching control workers who did not have badges used in the same machine factory
Results: the concentration of urinary double phenol A in epoxy resin sprayer was higher (median 1.
06 μ mol/mol)
Compared with the control (median 0.
52 μ mol/mol).
Compared with the control group, the concentration of urine metabolites in organic solvents used by epoxy workers was higher.
Endocrine examination showed different concentrations of follicle stimulating hormone (FSH)
Between epoxy sprayers (median 5. 3 mIU/ml)
And control (median 7. 6 mIU/ml).
Follicle stimulating hormone has a slight correlation with urinary shuangphenol a, but is not related to the metabolites of organic solvents.
There was no difference in the concentration of progesterone and free testosterone between the two groups.
Conclusion: BADGE may be endogenous.
The results suggest that double phenol A may interfere with the secretion of follicle stimulating hormone in men.
The clinical significance of shuangphenol A on endocrine interference needs further study.
Subjects and methods subjects and samples collected 42 male workers, their job was to spray badges in a machine factory and two related factories in Aichi Prefecture using mixed organic solvents as epoxy resin hardening agents as exposure workers in this study.
They include all the workers who use badges in these factories.
According to the product specification sheet of the seven hardening agents used, they contain 10-30% badges.
The product table shows that these reagents also contain toluene (0–30%), xylene (0–20%), 2-ethoxyethanol (0–20%), 2-butoxyethanol (0–20%)
, A isotinone (0–30%).
The workers used the above agents in an incomplete and closed spray booth.
They are responsible for spraying for at least three hours a day, wearing protective devices during spraying, but their workplace atmosphere is polluted.
The main information label may produce A double phenol inside.
Double phenol A may interfere with the secretion of hormones in men.
The policy implications of the effect of bisphenol A on endocrine disruption clinical significance should be further investigated in male workers exposed to bisphenol A.
To select control objects, 82 male workers of similar age to epoxy workers were randomly selected from 1202 fitters who did not use badges in the same factory.
No one refused to be recruited for the study.
The final selection of 42 workers as controls matches each epoxy worker by age (±3)
And the number of cigarettes per day.
The study was conducted in accordance with the Helsinki Declaration.
All subjects participated in the study as volunteers and gave written informed consent. Mean age (37±9, 38±10)
, Percentage of current smokers (86%, 86%)
Number of smokers/day (21±7, 21±6)
The epoxy sprayer is comparable to the control.
In epoxy sprayers, the percentage of drinkers decreased significantly (43%)
Than in the control (57%)(mobile phase (A)
Acetone-water-phosphate (20:79. 8:0. 2); mobile phase (B)
Acetone-water-phosphate (80:18. 8:0. 2);
25% B (linear gradient program0–28 min), 25%B–100%B (28–37 min);
360, 400, 440, 480, 520, 560, 600, 640 mV and.
Using the reaction curves in these eight channels, the peak value of biphenol A was confirmed.
The detection limit of double phenol A in this system is about 10 pg (0. 05 pmol).
The concentration of double phenol A passes through the linear regression line of standard double phenol a (Tokyo Kasei Co. , Tokyo, Japan)
And adjusted by the recovery rate of the internal standard.
The recovery rate of double phenol A and internal standard is about 100%.
The coefficient of variation of the measure was
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